 
Self-assembling
Peptide Systems in Biology, Medicine and Engineering
By Amalia
Aggeli (Editor), Neville Boden
(Editor), Shuguang Zhang (Editor)
Published on / after 2001
at £98.50 by
Kluwer Academic Publishers.
1st edition , ISBN
0792370902 0-792-37090-2 ,
Hardback, 372
pages. Unused and unread, overall condition:
Very good.
Info
This text
concerns the intrinsic self-assembling behaviour
of peptides and the implications of these
properties for a broad range of applications.
These include protein conformational diseases,
the engineering of nanostructured biodegradable
and biocompatible polymeric materials with
potential applications in tissue engineering,
biomedical devices, industrial fluids and
personal care products. This area of endeavour
is outlined in a series of 25 articles summarizing
lectures presented at the meeting on this
topic held in Crete in July 1999. The articles
address generic issues making the text readily
amenable to postgraduate students, academics,
and research scientists interested in new
challenges at the physical sciences - life
sciences interface.
Booknews
It has long been recognized that, in silk,
polypeptides assemble into structures of high
flexibility and high strength, but it is just
now being realized that peptides can self-assemble
into a variety of non- protein-like structures,
including fibrils, fibers, tubules, sheets,
and monolayers. With an eye towards the material
and medical benefits of such structures, these
proceedings of a July 1999 workshop on the
topic are presented. The idea that functionality
can be programmed into the self-assembled
structures is central to the 24 contributions,
which look at such specific topics as ribbon-like
lamellar structures from chain-folded polypeptides,
design of self- assembling peptides as catalyst
mimetics using synthetic combinatorial libraries,
exploiting peptide self-assembly to engineer
novel biopolymers, and assembly modulation
of channel-forming peptides. Annotation c.
Book News, Inc., Portland, OR (booknews.com)
Foreword
Ch. 1 Exploiting Peptide Self-assembly to
Engineer Novel Biopolymers: Tapes, Ribbons,
Fibrils and Fibres 1
Ch. 2 Ribbon-like Lamellar Structures from
Chain-folded Polypeptides 19
Ch. 3 Design of Self-assembling Peptides as
Catalyst Mimetics Using Synthetic Combinatorial
Libraries 35
Ch. 4 Thermodynamics of Protein-Protein and
Peptide Interactions 47
Ch. 5 The Mechanism of Amyloid Formation and
its Links to Human Disease and Biological
Evolution 65
Ch. 6 Transgenic Plants for Large Scale Production
of Peptides and Proteins 75
Ch. 7 Assembly Modulation of Channel-forming
Peptides 87
Ch. 8 Molecular Casting of Infectious Amyloids,
Inorganic and Organic Replication: Nucleation,
Conformational Change and Self-assembly 105
Ch. 9 Structure and Stabilization of Self-assembling
Peptide Filaments 113
Ch. 10 Designed Combinatorial Libraries of
Novel Amyloid-like Proteins 127
Ch. 11 Design of Synthetic Branched Chain
Polymeric Polypeptides for Targeting/Delivering
Bioactive Molecules 139
Ch. 12 Amyloid-like Fibrils from a Peptide-analogue
of the Central Domain of Silkmoth Chorion
Proteins 161
Ch. 13 Amyloidogenesis of Islet Amyloid Polypeptide
(IAPP) 171
Ch. 14 Engineering Self-assembly of Peptides
by Amphiphilic 2D Motifs: [alpha]-to [beta]
Transitions of Peptides 187
Ch. 15 Model Signal Peptides: Probes of Molecular
Interactions During Protein Secretion 207
Ch. 16 Structure, Folding and Assembly of
Adenovirus Fibers 221
Ch. 17 Solving the Structure of Collagen 235
Ch. 18 Disulfide Bond Based Self-assembly
of Peptides Leading to Spheroidal Cyclic Trimers
243
Ch. 19 A New Circular Helicoid-Type Sequential
Oligopeptide Carrier for Assembling Multiple
Antigenic Peptides 257
Ch. 20 Molecular Recognition in the Membrane:
Role in the Folding of Membrane Proteins 273
Ch. 21 Novel Peptide Nucleic Acids with Improved
Solubility and DNA-binding Ability 295
Ch. 22 Chiral Lipid Tubules 311
Ch. 23 [Delta]-T[subscript t]-Mechanism in
the Design of Self-assembling Structures 323
Ch. 24 Self-assembling Peptide Systems in
Biology and Biomedical Engineering 343
Index 361
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