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Poison bottles are identified by having some type of raised design on the surface so it could be determined, even in the dark, that the contents of these bottles should not be taken In addition the bottles were often of unusal shape. These have had good appeal to collectors for many years because the bottles are frequently found in cobalt and amber. American poisons in any other color are rare. English poisons common in cobalt and green, but rare in amber, have been imported in large quantities over the last dozen years. Childhood poisonings were wide-spread in the 19th century and often the subject newspaper articles and debates. The drug industry responded by making the bottles highly colored, ribbed, knobbed, or odd shaped. Most collectible poison bottles were manufactured primarily during the late 19th and early 20th century. Government regulation of the sale of dangerous substances eventually ended the poison bottle era.